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System: Windows 10

We currently have the Box Sync folder on the system's primary storage drive.

Is it possible to also sync files that are on a secondary drive, on the same PC?

Hi Jeff, 

Welcome to the Box Community!

Multiple instances of Box Sync cannot be run on a single machine. Only one Box Sync process can be running on a machine at any given time.

Please see Box Sync FAQs for more questions on running Box Sync app on your machine.